Libido, Sleep and Depression (Uridine)

INCONSISTENCIES IN HEALTH

I'm going to talk about boners again. Chill. If it weren't for boners you wouldn't be here. Actually, that's one of the reasons my blog is titled with the word FUCK, so that my reader base are only people I can actually help. It flouts the kind of serious compromises to quality of life which result from pretended offense to things which inherently have no offense. Swearing and sex bring joy to life. People who swear are woke. They are open to intellectual challenges and discovering truth as it is, not as they want it to be. The reason I was able to heal myself from debilitating health conditions is because I was not offended by challenges to long-held ideas and concepts. I not only heard new information but put it to use. People who blush at bad words and human sexuality, who loathe their bodies and shame others live as if science is a choice, liability mutable, and truth relative, then persist through self-defeating behaviors even after their negative consequences become unbearable. I know many men (straight, conservatives) with erectile dysfunction who believe there is no connection between the foods they choose to eat and their lack of boners and instead try to blame jerking off or pornography as if it has any basis in science (it doesn't). To be fair, their attitude is actually a result of their compromised hormonal state, more sensitive to upsets and frustration, all the while sensing that something is not right while hoping the unsettled feeling will just go away. But they continue believing this and never get better, instead resorting to band-aid boner aids which have their own debilitating health consequences while I, a hedonist homosexual, enjoy massive erections and a rewarding sex life while also having the best sleep of my life.

People with slowing libidos always have problems with sleep and mood, or at least will develop the additional issues within a relative short time of each other (libido seems the last function to go, after mood and sleep). Even though these conditions always present concurrently (complete loss does not immediately happen all at once, but over a period of time) they are addressed as separate and unrelated, which is exactly why no one has plain solutions to their remedy. When a man or woman's libido declines it is experienced as a dulling of sexual fulfillment, and the person often wrongly mistakes though experiences those neurological, physiological changes for a decline in attraction to a partner or private sexual obsessions. This decline in the nervous system's sensitivity also occurs during or just after peak sexual development (between 30-40 years old). Since the physical nervous system isn't functioning rightly, but the brain is, mental stimulation becomes the only possible source for real sexual gratification. Sufferers experience this as a sort of intimacy crisis, having no mental stimulation from their partner because their relationship to the partner is shallow, and now no physical stimulation for the decline in their physical health. Restore the physical health of the sex response and suddenly any physical contact is again as fulfilling as it was during youth and really has nothing to do with pornography or attraction. To fix the mental stimulation there needs to be a deeper intimate connection, but that is beyond the scope of this article.

When I was 26 I spent nearly a year of my life with constant sinus infections. I could never fully breathe through both nostrils at once, and as soon as my last sinus infection cleared up another would start to develop within a week or two, and I would have to return to the doctor who suggested I have surgery on my nose. I didn't understand why surgery would fix a problem with germs, and I am not as eager to go under the knife as people tend to be these days. I also had developed sleep issues, though not as severe as they would become, and problems with my emotional health. Thankfully I went on a date with a handsome nurse. We went to lunch and I mentioned my sinus issues. "You're probably allergic to gluten," he said. "What's gluten?" Actually, I knew what gluten was. I've been a cook for quite a while and liked to make my own breads occasionally, especially in the form of pizza. But he explained how gluten can cause allergic reactions, but most people aren't aware of it because it takes up to a full day for food to transit to the lower intestine, which is where the allergic reaction takes place, and many people erroneously identify other foods as the source of their complaints. True to this misidentification I had thought dairy was my problem and had given it up to no avail. Desperate to have some relief from my constant stuffy, pounding head I immediately stopped eating all sources of gluten—wheat, barley, and even oats. I still clearly remember the day that both of my sinuses opened at once, a week later. It was an epiphany, heralded by the triumphant return of fresh air flowing freely through my head for the first time in a long, long time.

Aside from the occasional mistake, or rabid craving for pizza, for the next six years I cut wheat entirely out of my life. After my battle with cancer and alcoholism (and accutane) and the return of my health I mistakenly thought I could attempt the consumption of wheat once more, but even after avoiding wheat for very, very long stretches of time even a few slices of pizza will give me severe insomnia. Even so, I was surprised a few months ago when I gave into my cravings and had not one, not two, but FIVE pieces of delicious mom-and-pop-shop pizza that showed up magically at work one day, fully expecting to have insomnia (it was Friday so I figured I could sleep on Saturday to recover) but found myself later that night having some of the hardest, most massive erections I'd had in years and took several orgasms to put away. I felt like a teenager, though when I was a teenager I didn't even have erections of this kind—the ones that men and women alike dream about. 

I was extremely confused. Why did a food which gave me insomnia also give me massive erections? My libido was not lacking by any means, and my erections were constant and easy, but nothing like what occurred after that pizza. Knowing what I did about food I didn't think it was a feature of normal bread wheat, but I hadn't yet figured out the how and why. 

URIDINE, DNA AND RNA

I have a fail-safe supplement I fall back on if ever having serious insomnia. It works every time, though it isn't needed every time. I first read about it casually mentioned in an article, but later found many studies on its use to improve sleep and depression. Uridine monophosphate. Uridine is a nucleoside involved in the synthesis of RNA and DNA. I haven't talked about it in articles before because it's expensive, and I also don't really know how it works (no one does, actually). The study which shows uridine's helpfulness in depression also suggests using fish oil (DHA) with it, but the reasoning in the study for DHA is very poorly formulated and not proper science, and you should not use DHA as it is highly toxic and inappropriate for the human metabolism. But I understood the other rationale behind using uridine and so I sent off for some. The first time I took Uridine I was tired for two days. Tired is not the right word actually, because it connotes exhaustion. Sleepy is better. Just one dose of it makes me very sleepy. Uridine just so happens to occur in human breast milk, but is more concentrated in the evening or at night, to help lull restless babies to sleep (which incidentally is one of the reasons pumped breast milk should be fed to infants at the same time of day it was expressed, or you can have a wakeful, cranky baby during the night). Other studies on Uridine show significant improvement in sleep quality, glycogen synthesis, and depression when supplementing uridine. Uridine is synthesized by our liver (from Thiamine, I think—there's not a lot of comprehensive information on it which is partly why its function is so poorly understood). Diabetics and other metabolic illnesses often present with low serum levels of uridine. Since many derangements in health are connected to proper glycogen use and storage, uridine is a very effective therapy for glycogen related issues. From my own experience and from the science I've read it is clear that uridine benefits sleep and mood, and also erections. Whenever I take uridine I get the same kind of massive erections as I got eating that pizza. But there is no uridine in pizza, and uridine as a supplement is expensive and, as I suspected, unnecessary to supplement. Since uridine is not obtained from diet, it seemed there was some other factor in its metabolism I was not yet aware of. 

FOLATE AND URIDINE

There are studies which show that a folate deficiency causes a very severe derangement of uridine metabolism into DNA (where it's supposed to go to RNA). I won't pretend to know the why or what with DNA—that's about as far as my knowledge on biology goes, but these studies make it clear that the problem with mood, sleep, and libido in connection with Uridine is not a deficiency of it but the inappropriate misdirection of it caused in turn by folate deficiency. Even supplementing Uridine doesn't permanently fix its deficiency, and getting adequate folate (which is NOT the same as folic acid supplement) is as effective as taking uridine itself. Since our bodies make enough uridine even in times of compromised health it isn't necessary to supplement uridine, but to ensure proper and sufficient access to folate. The reason I experienced such an improvement in erections from that pizza is because bread wheat is fortified with folic acid, a synthetic form of folate (the synthetic by the way is linked to several studies showing the synthetic form promoting cancer, so don't take it, and yet another reason to avoid fortified flour). But because wheat also causes its own deleterious and inflammatory side effects, and is also fortified with reactive and toxic iron, wheat is not a good source to obtain folate, and also because folic acid depletes vitamin B12, whereas natural folate does not. 

The best source of folate is liver and cooked leafy vegetables like spinach (do not eat raw spinach as cooking destroys most of the anti nutrients). There is so much folate in liver or spinach that not very much is required to get theraputic doses. But folate can also be destroyed or depleted by high-iron and hypothyroid states (or alcohol and dieting), which is why a person can have a functional deficiency even while getting the recommended amount in their normal diet, and it would be helpful to read my article The Cure For Hypothyroidism to understand how Vitamin C protects other vitamins from oxidation. This knowledge will help maximize retention and utilization of folate (but never take vitamin C at the same time as  high-iron foods like liver), and thus Uridine. Of course, merely getting vitamins is no guarantee of good health nor the restoration of metabolic processes like sleep, libido, and mood. It is dependent on a diet generous in carbohydrates, especially fruit and vegetables, plenty of protein, and composed of only good fats. The fat composition of your diet is one of the most crucial aspects to maintaining or restoring health, and you can read more about fats in the diet in The Truth About Fat. More information on how specific vitamins and hormones affect libido can be read in my article Erections!

OTHER BENEFITS OF URIDINE MAINTENANCE

There is a lot of research and well-considered theories that the improper incorporation of Uridine into DNA is a major cause of not only sleep and mood issues but also cancer and other serious metabolic disorders. But a folate sufficiency, protected by high levels of vitamin C, can ensure the proper function of uridine and help restore natural sleep, libido, and temperament. 

 

URIDINE SUFFICIENCY LIST

REGULAR CONSUMPTION OF HIGH-FOLATE FOODS LIKE LIVER or COOKED LEAFY GREENS. 
REGULAR/ADEQUATE CONSUMPTION OF THIAMINE (B1)
MAINTAIN HIGH BODY VITAMIN C (do not take Vitamin C with high-iron foods)
IF FOLIC ACID SUPPLEMENTATION IS NECESSARY, USE IN SMALL DOSES
URIDINE CAN BE SUPPLEMENTED FOR IMMEDIATE RELIEF IF DESIRED